How Many Cigarettes Are Equivalent to a Vape? Understanding the Comparison How many puffs of vape is equal to cigarettes Facts about nicotine and tobacco alternatives to cigarettes The nicotine content of many 2ml nicotine pods for multi pod devices is equivalent to a pack of 20 cigarettes. If you don't smoke, don't vape. And if you are smoking E Cigarettes, Vapes, and other Electronic Nicotine Delivery Systems (ENDS) FDA