Can your lube affect your chances of getting pregnant? Yes some lubricants can make it harder for sperm to reach the egg. Look for sperm safe or fertility friendly formulas that mimic your Pre Seed Fertility Lubricant Sperm Friendly Lube First Response Trying to conceive? Then the lubricant you choose really matters. Most regular lubricants can actually slow down sperm, but fertility friendly lubricants are designed to support natural conception. Here's why they're better Do Lubricants Affect Pregnancy Chances? Many couples wonder if lubricants can prevent conception. Oil based lubricants (like Vaseline, coconut oil, creams, lotions) can slow down sperm movement and reduce pregnancy chances. How Sexual Lubricants May Affect Fertility What You Should Know Midwest Fertility Center